For a Human Factors approach, either it's behavior, intrinsic (illness/injury) and/or an engineering issue.
Engineering - softer materials can help reduce vibrations, but can sometimes result in extra grip force. A slightly smaller diameter can be helpful if the current circumference is too large. In your case, I don't think you have petite hands. If the glove is too thick, then force grip is undesirably increased. Try a thinner glove or better material in the palm. My Racers are made of kangaroo leather and have a special thin grip material sewn over it.
Behavior - the grip should come from the pinky, ring and middle finger and less from the index. If you can't easily wiggle the middle joint of the fingers, the grip is too tight. In Kendo and aikido, this is essential for sword and grappling.
Intrinsic - look up Raynaud's disease which is a constriction issue from excessive grip/vibrations and constriction of blood vessels. If one feels the engineering and behavior issues are controlled or mitigated, then you should get an examination from your MD.
My personal experience has been that the softer grips help pad a hard spot since rubber and bar ends have a lot of vibration reduction. My grip force is much less than when I first started riding the ST. I would estimate half. With training and experience, other body parts have taken over like thighs, groin and stomach. I use tank grippers to aid that. I replaced the OEM grips with Superbike Progrip 699 brand because I like the tackier rubber and it was just a tad more cushion near the blade of my hand. Plus, it has 3 grooves for wire ties.