Generally speaking if Windows 10 will let you install it, it will run. Windows may interrupt the install and ask you if you want to install it in Windows 7 or XP mode.
The biggest problem might be 32bit program, 64bit Windows. That program probably wants to use its own USB to Serial drivers so you might have to play with that.
I had trouble with it. Primarily it was due to the older kit I have needing a serial port. If you have a USB kit, maybe it will be OK. In the end I switched to GuzziDiag and bought the needed cables for a few bucks on Amazon. VDST was all the rage when it came out because it was pretty much the only way home users could connect. Those days are long gone and the free GuziDiag is better in many ways. Certainly connects better and is more stable. Maybe the newer version of VDST is better, but I looked at it and it seems pretty pricey when you can get what you need for home use with freeware.