norcal, I use my ST3 as a commuter pretty much daily when the weather is nice. I've had no problems. My only wish is that I lived further from work!
Will this be your sole means of transport? City driving? Do you do your own maintenance? Buying new or used? The reason I ask is that the bikes tend to be geared a bit high...city driving can be a bit tough (the ST3 really isn't happy until she's doing 20–25 mph, there's quite a bit of clutch play in stop and go traffic).
Maintenance costs tend to be higher with Ducatis than other brands (particularly the Japanese brands). I do my own service and have other means of transportation (so if I'm stumped I don't have to stress out about getting somewhere). If you buy new, you would probably take the bike back to the dealer for the first couple services...before you buy, ask the service department for the service costs of the particular model you're interested in. This will give some heads up as to the cost of ownership (if you choose to go the dealer service route). If you buy used and opt for doing you own service, there are plenty of parts suppliers that offer the routine service parts (belts, shims, oil and air filters, etc.) that will help keep the costs down.
If the bike makes you happy...buy it. Ducatis have lots of character that you'll probably enjoy! Just my 2 cents worth.