I just purchased a new '06 ST3, waiting for it to be shipped as we speak. When I get it I am going to drain the oil, replace the filter and fill it with 10W-40 Valvoline non-synthetic.
I am then going to break it in per mototune's recommendation, the street method. After 20 miles I will drain the oil and replace the filter with the same as above and probably run that for 1,000 to 1,500 miles. From that point forward I will use a synthetic but same weight, preferable for twins.
I have never done it like this before so this is a first. I really won't know if its better than the "recommended" method but if it blows up, burns oil, runs bad etc I will post it here.
This is an endless debate with great points on both sides. Since I have tried the other approach (with no adverse results that I know of) I want to try this approach. I typically have not kept my bikes very long but that has changed so I don't have a good long history with the recommended break in. It was a Honda though and I personally think they are the best built bikes in the world, just everyone has one.
For what its worth, this will be my approach. Hell it might be wrong but damit I will do something.